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Abstract The main purpose of this paper was to assess the current state of science on oral leukoplakia. Nowadays there are no currently accepted markers to distinguish those that may progress to cancer from those that may not. The current golden standard is considered the presence of epithelial dysplasia on the tissue biopsy of the lesion. Proliferative verrucous leukoplakia is a rare form of OL which has multiple recurrences, is refractory to treatment and has malignant transformation in a short period. It is considered a true premalignant lesion. The management of oral leukoplakia varies from a "wait and see" attitude and topical chemopreventive agents to complete surgical removal.

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Abstract The main purpose of this paper was to assess the current state of science on oral leukoplakia. Nowadays there are no currently accepted markers to distinguish those that may progress to cancer from those that may not. The current golden standard is considered the presence of epithelial dysplasia on the tissue biopsy of the lesion.

Proliferative verrucous leukoplakia is a rare form of OL which has multiple recurrences, is refractory to treatment and has malignant transformation in a short period. It is considered a true premalignant lesion. The management of oral leukoplakia varies from a "wait and see" attitude and topical chemopreventive agents to complete surgical removal. Oral leukoplakia OL is the most frequent potentially malignant disorder of oral mucosa. Although OL is mentioned in clinical reviews since 2 , it was first defined by World Health Organization in 3 as a white patch or plaque which cannot otherwise be characterized clinically or pathologically as any other disease.

Since then until now, the meaning of oral leukoplakia is not very much changed. In 4 , after an international symposium held in Uppsala, Sweden in the definition, was added that oral leukoplakia is not associated with any physical or chemical cause, excepting smoking and it can become cancer.

In it was decided that the name of leukoplakia should be limited only to a clinical diagnosis defined by exclusion of other white lesions such as oral lichen planus, white sponge nevus, nicotine stomatitis, leukoedema etc 5.

In van der Waal 6 proposed a new definition which seems more oportune as it includes the histological confirmation "A predominantly white lesion or plaque of questionable behavior having excluded, clinically and histopathologically, any other definable white disease or disorder". Demographic distribution The pooled estimated prevalence rate of oral leukoplakia in varied between 1.

For this estimated rate, the author- Stefano Petti, in a meta-analysis including 23 primary studies from all over the world published in the period found no difference between geographical areas and between younger and older patients.

OL is often found among men, and its prevalence increases with age advancement. It has been estimated that it mainly affects men over 40 years 8. Etiology The etiology of OL is considered multifactorial, but smoking is appreciated to be a frequently involved factor. It is much more common among smokers than among non-smokers 5. Alcohol is thought to be an independent risk factor 4 but definitive data are still lacking. There are conflicting results of studies related to the possible role of human papillomavirus infection.

As OL can mimic a large variety of lesions, in case a possible causal factor is suspected such as dental restoration, mechanical irritation. In the later case a subsequent evaluation in 4 weeks is needed 6. Clinical appearance OL is classified in two main types: homogeneous type which appears as a flat white lesion and non-.

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Idiopathic leukoplakia lingualis.

Gen Dent. Idiopathic leukoplakia lingualis. A year-old man had a nonspecific leukoplakia of the tongue. It was of recent onset and had no readily apparent etiology. From the differential diagnosis of seven conditions, biopsy was consistent with a benign hyperkeratotic process. Although several atypical cells were noted in the epithelium, no foci of dysplasia or frank squamous cell carcinoma were observed.

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Lengua negra vellosa

Dijora Significance of resistance of herpes simplex virus to acyclovir. Neurology Chapter related topics Lingual Tremor. OHL is associated to the Epstein-Barr virus and presents clinical and histological defined characteristics. Katz MH et al. For this purpose, 42 HIV-infected patients were selected, with 69 oral hairy leukoplakia treated at Orestes Diniz. After 6 months, 15 of the 81 patients from the A group were excluded as they have initiated antiretroviral therapy. El VIH y la boca.

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